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Most human tumours are heterogeneous, composed of cellular clones with different properties present at variable frequencies. Highly heterogeneous tumours have poor clinical outcomes, yet the underlying mechanism remains poorly understood.
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Drug resistance remains an elusive problem in cancer therapy, particularly for novel targeted therapies.
Full ArticleBig Bang model of colorectal tumor growth
A Big Bang model of human colorectal tumor growth. What happens in the early, still undetectable human malignancy is unknown because direct observations are impractical.
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